Research

In an effort to improve clinical care for patients with vascular conditions, Dr Chua continues to be actively involved in publishing research papers in international medical journals as well as in the development and research of vascular devices. He has received multiple grants from A*Star and SMART and also holds patents and invention disclosures for novel vascular surgery devices.

Publications

Book Chapters

B Chua, P Robless, “Ruptured and Leaking Abdominal Aortic Aneurysm”, Atlas of Complicated Abdominal Emergencies, TK Ti, D Lomato (Editors), World Scientific Publishers, ISBN978-981-4412-148.

Irani FG, Gogna A, Chua SY, Taneja M, “Iliac and SFA interventions in chronic limb ischemia’, Urgent Interventional Therapies. In press.

Journal Reviews

Invited Reviewer, Annals Academy Medicine of Singapore.

Journal Publications

Jack Kian Ch’ng, Manish Taneja, Benjamin Soo Yeng Chua, “Repair of a complex post-EVAR type III endoleak using a chimney aorto-uniiliac stent graft and femoro-femoral crossover bypass”, Journal of Surgical Case Reports 2013; 2013(4): 10.1093/jscr/rjt027.

Hennedige T, Chua B, Taneja M, “Modification of the Sandwich Technique to Preserve Flow in the Hypogastric Artery After Endovascular Repair of Aorto-iliac Aneurysmal Disease: Our Initial Experience With Two Cases”, Annals of Vascular Surgery, Vol 26, Issue 7, Pages 1011.e1-1011.e5, October 2012.

Sharma VK, Chua B, Teoh HL, Chan BP, Sinha AK, Robless PA, “Chronic brainstem ischaemia in subclavian steal syndrome”, J Clin Neurosci. 2010 Jul 8. [Epub ahead of print].

Benjamin Phak Boon Tow, Benjamin Soo Yeng Chua, Stephanie Fook-Chong, Tet Sen Howe, “Concurrent fractures of the hip and wrist: A matched analysis of elderly patients”, Injury Vol. 40, Issue 4, Pages 385-387, April 2009.

Chua B, P Robless, G Standsby, “Endoluminal stents for superficial femoral and popliteal artery occlusions in patients with lower limb peripheral artery disease”, Cochrane Database of Systematic Reviews 2007 Issue 3. Published protocol for ongoing review in collaboration with The Cochrane PVD Group in Edinburgh, UK.

Chua B, Owen WF Jr, Reddan D.N., “Peripheral vascular disease and ESRD: what is the most appropriate intervention?” Int J Artif Organs 2002 Jan;25(1):3-7.

B Chua, “Critical Appraisal of the Medical Literature – an application framework”, Cancer Update, National Cancer Centre Singapore, Vol 3, 2004.

AYJ Lee, BSY Chua, TS Howe, “One-year outcomes of hip fracture patients admitted to a Singapore hospital: Quality of life post-treatment.” Singapore Med J 2007;48(11):996-999.

Chen JLT, AYJ Lee, BSY Chua, TS Howe, “Hip fractures in the elderly: The impact of co-morbid illnesses on hospitalization costs.” Ann Acad Med Singapore 2007;36:784-787.

Griffith, T. F., B. S. Chua, et al. (2003). “Characteristics of treated hypertension in incident hemodialysis and peritoneal dialysis patients.” American Journal of Kidney Diseases 42(6): 1260-9, 2003.

Szczech L A, Reddan D N, Klassen P S, Coladonato J, Chua B, Lowrie E, G, Lazarus J M, Owen, W F Jr. “Interactions between dialysis-related volume exposures, nutritional surrogates and mortality among ESRD patients.” Nephrology Dialysis Transplantation 18(8): 1585-91, 2004.

L A Szczech, P S Klassen, B Chua, S S Hedayati, M Flanigan, W M McClellan, D N Reddan, R A Rettig, D L Frankenfield, W F Owen Jr, “Associations between CMS’s Clinical Performance Measures project benchmarks, profit structure, and mortality in dialysis units.” Kidney Int 69: 2094-2100, 2006.

Clinical Research Projects

Development of a Novel Guide Wire to be used in Angioplasty for Peripheral Arterial Disease

Oct 2014 – Present

Principal Investigator, A*STAR Biomedical Engineering Programme (BEP) 2013 Grant Ref no. 1421480019, “Forward-Sensing Intravascular Tactile Sensor (IVTS): Endovascular Guidewire Intervention”, funded for SGD 500,000 for 2 years.

2009

Science and Engineering Research Council/ A*STAR EHealth Medical Device Innovation Grant #0921480070, Medical Principal Investigator, “Development of a pressure sensor guided steerable endovascular catheter”, funded for 3 years at S$2,094,030, project kickoff 15 Sep 2009.

2009

SG Provisional Patent Application: Ultra Miniaturized, Highly Sensitive and Robust Tri-axial Force Sensor for Medical Devices and Method of Forming ETPL Ref: IME/P/05712/00/SG IME Ref: PAT09-045/BEP-011, Application No.: 200907245-5, Filing Date: 30 Oct 09.

Development of a New Self-Monitoring Vascular Haemodialysis / Bypass Graft

2012

Science and Engineering Research Council/ A*STAR 3rd Biomedical Engineering Programme (BEP) Grant Call Medical Device Innovation Grant #1211480006, Medical Principal Investigator, “Real-time Prosthetic Graft Flow Monitoring Systems”, refunded for 3 years at S500,000, project kickoff 15 Mar 2013.

2009

Science and Engineering Research Council/ A*STAR EHealth Medical Device Innovation Grant #0921480069, Medical Principal Investigator, “Development of a biosensor prosthetic graft”, funded for 3 years at S$2,055,560, project kickoff 15 Sep 2009.

2009

SG Patent Provisional Application: Implantable Device for Continuous Monitoring of Blood Flow with Wireless Interface and Method of Deploying ETPL Ref: IME/Z/05711 IME Ref: PAT09-044/BEP-01, Application No.: 200907244-8, Filing Date: 30 Oct 09.

Development of a Novel Stent Graft Device to Treat Aortic Aneurysms

2012

Singapore-MIT Alliance for Research & Technology (SMART) Proof of Value Grant Principal Investigator, “Development of a novel endovascular implant for aortic aneurysms”, funded for 2 years for SGD 250, 000, prototype testing and animal trials , kickoff May 2012.

2010

Singapore-MIT Alliance for Research & Technology (SMART) Ignition Grant 34BIO(IGN) Principal Investigator, “Development of a novel endovascular implant for aortic aneurysms”, funded for 1 year for SGD 50, 000, prototype development only, kickoff Oct 2010.

2010

SG Provisional Invention Disclosure and US Provisional Patent application: Flow Diversion Stent Graft For The Treatment of Aortic Aneurysms, NUS Industry Liaison Office, 2 Jun 2010.

Development of a New Percutaneous Mitral Valve Implant

2013

Science and Engineering Research Council/ A*STAR 3rd Biomedical Engineering Programme (BEP) Grant Call Medical Device Innovation Grant 08_POC_025 Medical Co-Investigator, “Percutaneous Mitral Valve Replacement”, refunded at S$500,000, kickoff Sep 2013.

2011

Science and Engineering Research Council/ A*STAR Bioengineering Programme Grant #1031490004, Medical Co-Investigator, “Development of a Percutaneous Mitral Valve Replacement Device”, funded for 18 months at S$498,065, kickoff 1 June 2011.

Clinical Trial on a New Method to treat Peripheral Arterial Disease with Stem Cells

Sep 2014 – Feb 2015

Principal Investigator, Autologous Bone Marrow Stem Cells for Peripheral Vascular Disease, Pilot Clinical Service Trial, Singapore General Hospital, 4 cases done to date.

Other Research Projects

2013

Industry collaboration with Abbott Vascular, Principal Investigator, ESPIRIT trial – Worldwide first-in-man study on the use of biodegradable drug-eluting stent in AV fistula salvage, funded for 2 years for SGD 60,000, kickoff April 2013

2010

Ministry Of Health FY2010 Healthcare Quality Improvement & Innovation (HQI2) Fund Award, Co-Principal Investigator, “Surgical Performance Indicators: Choosing The Right Measure” (Reference HQI2F 2010/05) funded for 2 years at S$110,000, kickoff May 2010.

2008

Renewal, National University Hospital Leadership in Academic Medicine (NLAM) Grant (Scheme A), extension of existing grant to fund novel clinical outcomes research for an additional period of 1 year.

2006

National University Hospital Leadership in Academic Medicine (NLAM) Grant (Scheme A) to fund novel clinical outcomes research for a period of 1 year.

Ongoing Research Initiatives
  • Development of peripheral stem cell injections for DM lower limb salvage
  • Characterisation and development of flow pattern recognition for aortic aneurysms
  • Development of a cost-effective, virtual-realistic surgical interventional healthcare simulation platform
  • Collaboration with the Institute of Microelectronic, Singapore and the Science and Engineering Research Council, A*STAR – The Development of a Biosensor Coated Prosthetic Graft, primary device development stage
  • Collaboration with the Institute of Microelectronic, Singapore and the Science and Engineering Research Council, A*STAR – The Development of a Pressure-sensor guided angiographic catheter, primary device development stage
  • Development of a regional ASEAN-Plus clinical outcomes database in peripheral vascular disease
  • ESPIRIT trial – Worldwide first-in-man study on the use of biodegradable drug-eluting stent in AV fistula salvage