Lymph is a fluid that circulates around the body, carrying essential substances such as white blood cells, proteins, salts, fat, water, etc. Lymphoedema is swelling which affects the limbs due to failure of the vessels responsible for transporting the lymph. Lymphatic vessels serve to help drain fluid from the extremities as well as acting as an immune gatekeeper. Glands that filter lymph is known as lymph nodes.
Primary lymphoedema is rare and often due to the absence of lymph from birth or the failure of the lymphatic system to work overtime. Patients can present with swollen limbs at birth (congenital absence of lymphatics) or in their teenage years (delayed primary failure).
Secondary lymphoedema is more common and is often the result of surgery to remove the lymph nodes (e.g. surgery for breast cancer and axilla lymph node clearance) or radiation therapy to the lymph nodes (e.g. radiation to the groin or pelvic lymph nodes). Sometimes recurrent skin infections (cellulitis) can also damage the lymphatic drainage of the limbs.
Diagnosis requires:
The main aim of treatment is to reduce the limb swelling and restore functionality.